ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

Blog Article

Despite numerous studies on cancer western Hat treatment, cancer remains a challenging disease to cure, even after decades of research.In recent years, the cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpected side effects compared to existing therapies.However, the cancer vaccine faces obstacles to commercialization due to its low efficacy.Particularly, the Toll-like receptor (TLR) adjuvant system, specifically the TLR 7/8 agonist, has shown potential for activating Th1 immunity, which stimulates both innate and adaptive immune responses through T cells.

In this study, we developed ProLNG-S, a cholesterol-conjugated form of resiquimod (R848), to enhance immune efficacy by stimulating the immune system and Barrel Saddle reducing toxicity.ProLNG-S was formulated as ProLNG-001, a positively charged liposome, and co-administered with ovalbumin (OVA) protein in the B16-OVA model.ProLNG-001 effectively targeted secondary lymphoid organs, resulting in a robust systemic anti-tumor immune response and tumor-specific T cell activation.Consequently, ProLNG-001 demonstrated potential for preventing tumor progression and improving survival compared to AS01 by enhancing anti-tumor immunity.